BDBM50207145 CHEMBL3946995::US9550741, I-1

SMILES O=C(N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1)c1ccco1

InChI Key InChIKey=AAELEHAFAYIZRH-WGSAOQKQSA-N

Data  12 KI  5 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50207145   

Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Shanghai Institute of Pharmaceutical Industry

US Patent
LigandPNGBDBM50207145(CHEMBL3946995 | US9550741, I-1)
Affinity DataKi:  0.230nMpH: 7.7Assay Description:1. Experimental Materials(1) 5-HT2A Cell Transfection:This experiment utilizes the plasmid vector containing the gene of the 5-HT2A receptor protein ...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Shanghai Institute of Pharmaceutical Industry

US Patent
LigandPNGBDBM50207145(CHEMBL3946995 | US9550741, I-1)
Affinity DataKi:  0.230nMAssay Description:Displacement of [3H]ketanserin from recombinant human 5-HT2A receptor expressed in HEK293 cell membranes after 60 mins by scintillation counting meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Shanghai Institute of Pharmaceutical Industry

US Patent
LigandPNGBDBM50207145(CHEMBL3946995 | US9550741, I-1)
Affinity DataKi:  0.230nMpH: 7.7Assay Description:1. Experimental Materials(1) 5-HT2A Cell Transfection:This experiment utilizes the plasmid vector containing the gene of the 5-HT2A receptor protein ...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Shanghai Institute of Pharmaceutical Industry

US Patent
LigandPNGBDBM50207145(CHEMBL3946995 | US9550741, I-1)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at 5-HT2A receptor (unknown origin) expressed in CHOK1 cells co-expressing G-alpha 15 by Fluo-4 dye based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Shanghai Institute of Pharmaceutical Industry

US Patent
LigandPNGBDBM50207145(CHEMBL3946995 | US9550741, I-1)
Affinity DataIC50:  32nMAssay Description:Antagonistic activity at 5-HT2A receptor (unknown origin) expressed in CHOK1 cells co-expressing G-alpha 15 assessed as inhibition of serotonin-induc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed